The 05 Chopper has 3.8 fuel and the way the tank is position, may allow it to use more of the fuel.
Other factors may be the jetting and any other mods on the Chopper compared to the Mastiff. It is hard to do and apple to apple comparison on different bikes, even from the same year and make, however I would think you should get in the 42-44 MPG range with normal highway riding and should be safely be able to get 100 mile runs without having to sweat running out.
Myself and many other always go for the 100 mile fill up regardless of how much we may be able to push it for there is too many variables that effect the range, from headwinds, elevations, mods, etc and I do not want to hit reserve for that is like gambling!!!
I know that Knotso has the 06 Mastiff and if not mistaken he gets a good 100 miles before the pucker factor comes into play. Knotso how is you overall gas mileage anyway.