Sven story... an ongoing problem at another website, guy is fouling #2 plug only. I told him fuel related. Others chimed in throwing all sorts of variables and missing the one wire theory. I explained it well before and still swapped coils and ignition to no avail. Have yet to hear back. Anyway, I'll toss in the same variable of the full ign system and see if it makes sense...
Say the ignition unit is 1-4 pickup and a 2-3 pickup on an inline 4-cyl eng. Say the wire connector only shows two wires in the connector. That still says one continuous wire showing both ends at the connector. If 1 fails, all 3 fail as well. How can the flow continue without the other wire that is stopped between a total of 2 pickups? Ain't gonna happen chasing one fouled plug. Then it's fuel related, not ignition but one of the 4 carbs/injectors.
Say dual coil is 1-4 and the other coil is 2-3 on a 4-cyl. Same wire in-wire out. Ign key to one side of the coil, pickup is the trigger and that side. Can't foul one plug if a dual plug fires once and out that thick Y of a braid split [inside] for both plug wires. Has to be comp.
Back to your variable. Since the ign setup was not mentioned, back to a single coil, dual leads, and dual pickups at the ign-system [if applies]. If wire in-wire out holds true, it's not the coil, not the ign, not fuel.
Bad coil lead?