The density of AV gas is much less than automobile gas or race gas... for every gallon of AV gas passed through your carb jets you will have less fuel per pound compared to pump gas/race gas. This will lean out the air/fuel ratio and produce less power if jetted for pump gas. It is also made to run at a diffrent altitude than pump gas/race gas for a car. Trust me on this as I have many hours of dyno time with engines from 281cid-600cid. It can be done but it needs proper timming,jetting,air bleeds in the carb to do so. It is even more critical with a boosted engine.
If you take the time to remove the edges that are sharp on the piston/combustion chamber, have the quench set on the money,use aluminum heads, and the right head gasket. you can run pretty high compression even on pump gas. I have had engines run up to 12.3.1 N/A that will run well on pump gas 93. They were set up to run with that gas as a starting point. I have a good number of hours with blower motors and ways to make them work with high boost on the street as well.